Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas:1192362-32-5: dota-lm3 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1192362-32-5: dota-lm3 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1192362 -}32-5: DOTA-LM3 |
| Kev piav qhia | DOTA-LM3 yog ib qho kev xaiv zoo heev somatostatin receptor 2 (SSTR2) antagonist-raws li radionuclide conjugate peptide, covalently txuas los ntawm SSTR2 antagonist peptide LM3 thiab macrocyclic chelator DOTA. Lub LM3 moiety tshwj xeeb khi rau SSTR2 receptors tau nthuav tawm heev ntawm cov qog cell nto nrog nanomolar affinity, thiab tsis induce receptor internalization, tso cai rau khi rau ntau qhov chaw receptor. Lub DOTA macrocycle tuaj yeem ruaj khov chelate ntau yam xov tooj cua hlau nuclides xws li ⁶⁸Ga, ¹⁷⁷Lu thiab ⁹⁰Y nyob rau hauv cov mob me me, txhawb nqa ob qho tib si PET duab thiab cov phiaj xwm kev kho mob radionuclide. Piv nrog rau agonist-hom somatostatin peptides, nws cov cuab yeej antagonist txhim kho cov teeb liab- rau- suab nrov piv ntawm qog cov duab thiab kho tau zoo. Nws yog cov cuab yeej tseem ceeb rau kev tshawb fawb theranostics ntawm SSTR- cov qog zoo. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₆₉H₉₃ClN₁₆O₁₉S₂ |
| Molecular Luj (Da) | 1550.16 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| DOTA-LM3 | DOTA-LM3 conjugate; SSTR2 antagonist chelate | Kev xaiv ntau yam SSTR2 antagonist, radionuclide chelation, neuroendocrine qog imaging, tsom radionuclide kho | Cyclic peptide LM3 conjugated rau DOTA macrocyclic chelator ntawm tus linker; LM3 tsim ib lub voj voog ruaj khov ntawm ib daim ntawv cog lus intramolecular disulfide, nrog kev hloov kho chlorophenylalanine los txhim kho affinity; DOTA chelates ntau nuclides xws li ⁶⁸Ga thiab ¹⁷⁷Lu | C₆₉H₉₃ClN₁₆O₁₉S₂ | 1549.62 | 1550.16 | Dawb peptide (chelated) | 8 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-DLM001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. nruj me ntsis kom tsis txhob muaj zog txo cov neeg sawv cev los tiv thaiv disulfide daim ntawv cog lus cleavage. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble hauv DMSO thiab DMF; me ntsis solubility nyob rau hauv physiological buffers, me ntsis txhim kho nyob rau hauv acidic tej yam kev mob. Disulfide daim ntawv cog lus tau nrawm nrawm thiab tsis ua haujlwm los ntawm cov neeg ua haujlwm txo qis. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DLM001 | Kev xaiv ntau yam SSTR2 antagonist chelate peptide rau qog radionuclide imaging thiab kho | DOTA-LM3 yog ib qho kev xaiv zoo heev somatostatin receptor 2 (SSTR2) antagonist-raws li radionuclide conjugate peptide, covalently txuas los ntawm SSTR2 antagonist peptide LM3 thiab macrocyclic chelator DOTA. Lub LM3 moiety tshwj xeeb khi rau SSTR2 receptors tau nthuav tawm heev ntawm cov qog cell nto nrog nanomolar affinity, thiab tsis induce receptor internalization, tso cai rau khi rau ntau qhov chaw receptor. Lub DOTA macrocycle tuaj yeem ruaj khov chelate ntau yam xov tooj cua hlau nuclides xws li ⁶⁸Ga, ¹⁷⁷Lu thiab ⁹⁰Y nyob rau hauv cov mob me me, txhawb nqa ob qho tib si PET duab thiab cov phiaj xwm kev kho mob radionuclide. Piv nrog rau agonist-hom somatostatin peptides, nws cov cuab yeej antagonist txhim kho cov teeb liab- rau- suab nrov piv ntawm qog cov duab thiab kho tau zoo. Nws yog cov cuab yeej tseem ceeb rau kev tshawb fawb theranostics ntawm SSTR- cov qog zoo. | Neuroendocrine qog kev tshawb fawb, kev tshawb fawb txog tshuaj nuclear kev tshawb fawb, tsom rau kev tshawb fawb radionuclide, kev tshawb fawb somatostatin receptor function, peptide-kev txhim kho tshuaj conjugate | Somatostatin receptor 2 (SSTR2); DOTA chelating pawg / radionuclide cab kuj |
Cim npe nrov: cas:1192362-32-5: dota-lm3, Tuam Tshoj cas:1192362-32-5: dota-lm3 manufacturers, lwm tus neeg, Hoobkas
