Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 914009-84-0 elsiglutide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 914009-84-0 elsiglutide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 914009-84-0: Elsiglutide |
| Kev piav qhia | Elsiglutide yog cov txheej txheem ua kom zoo rau ntev-ua haujlwm GLP-2 receptor siab-xaiv agonist. N-terminal site kev hloov pauv tseem ceeb txhim kho kev tiv thaiv rau dipeptidyl peptidase IV (DPP-IV) degradation thiab txuas ntxiv nyob rau lub sijhawm vivo. Nws tshwj xeeb khi rau GLP-2 receptors ntawm plab hnyuv epithelial hlwb, txhawb txoj hnyuv epithelial cell proliferation, inhibits apoptosis, nce plab hnyuv mucosal thickness thiab assorption cheeb tsam, thaum txhim kho plab hnyuv kab mob kev ncaj ncees thiab txo qhov mob-mediated mucosal puas. Siv dav hauv kev tshawb fawb txog kev siv tshuab thiab kho plab hnyuv peptide tshuaj txhim kho rau lub plab zom mov luv, tshuaj kho mob ua rau mob mucositis, kab mob plab hnyuv thiab kho mob plab hnyuv. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₁₆₆H₂₅₆N₄₄O₅₅S |
| Theoretical molecular hnyav (Da) | ~ 3769.20 (raws li qhov tseeb hluavtaws batch) |
| Hom qauv | Site-mutated hloov GLP-2 analog, 33-mer linear polypeptide |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Hloov kho hom | Ntev (aa) |
| Elsiglutide | Elsiglutide; ZP1848; GLP-2 analogue | Kev kho plab hnyuv mucosal, GLP-2 receptor agonism, Kev tshawb fawb luv plob tsis so tswj, DPP-IV degradation resistant, plab hnyuv thaiv kev tiv thaiv, gastrointestinal peptide | 33-mer linear caj qaum nrog Ala → Gly qhov chaw hloov ntawm txoj hauj lwm 2 | C₁₆₆H₂₅₆N₄₄O₅₅S (theoretical) | 3767.85 | 3769.2 | Ib qho amino acid qhov chaw hloov pauv | 33 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ELG001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | Khoom hmoov ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble nyob rau hauv dej thiab nruab nrab physiological tsis **. DPP-IV kuj tseem txhim kho, tab sis tseem ua rau endopeptidase degradation. Methionine nquag oxidation | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ELG001 | Ntev - ua yeeb yam GLP-2 receptor agonist uas txhawb txoj hnyuv epithelial proliferation / kho, txhim kho txoj hnyuv thiab txhim kho kev nqus dej hauv plab hnyuv loj | Los ntawm kev ua kom lub cev muaj zog ntawm endogenous GLP-2, Elsiglutide activates GLP-2 receptors nyob rau saum npoo ntawm plab hnyuv epithelial hlwb thiab crypt hlwb nrog siab selectivity, pib downstream cAMP/PKA thiab PI3K/Akt signaling pathways, txhawb nqa cryptstem cell proliferation Kev rov ua dua tshiab, nce villus qhov siab thiab mucosal thickness, thiab nthuav txoj hnyuv plab zom mov cheeb tsam. Lub caij no, nws inhibits epithelial cell apoptosis, upregulates nruj hlws ris protein qhia, txhim khu plab hnyuv mechanical barrier muaj nuj nqi, txo endotoxin thiab inflammatory factor translocation, thiab alleviates plab hnyuv inflammatory kev puas tsuaj. Piv nrog haiv neeg GLP-2, nws cov amino acid hloov ntawm txoj hauj lwm 2 tsis txhob ceev enzymatic cleavage los ntawm DPP-IV, ncua nyob rau hauv vivo ib nrab-lub neej los ntawm ob peb folds nrog ntev nyhuv. Cov molecule no ua haujlwm zoo li cov cuab yeej tseem ceeb peptide rau txoj hnyuv them nyiaj hauv plab hnyuv luv, tshuaj kho mob ua rau mob plab hnyuv mucosal kho, tiv thaiv mucosal hauv kab mob plab hnyuv thiab plab hnyuv ua haujlwm kev tshawb fawb, nrog rau cov hlau lead molecule rau kev txhim kho cov tshuaj tua kab mob tshiab peptide. | Kev tshawb fawb txog kev mob plab hnyuv luv, Kev kho tshuaj kho mob -induced plab hnyuv mucositis, mob plab hnyuv kab mob kev tshawb fawb, plab hnyuv muaj nuj nqi, plab hnyuv kho peptide, plab hnyuv mucosal regeneration | Glucagon-Zoo li Peptide-2 Receptor (GLP-2R); cAMP/PKA thiab PI3K/Akt signaling pathways; Txoj hnyuv epithelial proliferation thiab kho mucosal txoj kev |
Cim npe nrov: CAS 914009-84-0 elsiglutide, Tuam Tshoj cas 914009-84-0 elsiglutide manufacturers, lwm tus, Hoobkas
