Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1480724-61-5 vosoritide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1480724-61-5 vosoritide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1480724-61-5: Vosoritide |
| Kev piav qhia | Vosoritide yog ib qho kev ua kom zoo tshaj C-type natriuretic peptide analog. Nws xaiv activates natriuretic peptide receptor B (NPR-B), txhawb nqa chondrocyte proliferation thiab sib txawv, thiab nkoos endochondral ossification nyob rau hauv cov pob txha loj hlob phaj, yog li txhawb cov pob txha ntev thiab txhim kho qhov siab loj hlob. Nws muaj kev sib raug zoo tsawg heev rau NPR-A receptors thiab tsis muaj atrial natriuretic-zoo li hypotensive thiab diuretic phiv. Nws yog thawj hom tshuaj rau kev kho mob achondroplasia, siv hauv kev tshawb fawb xws li kev txhim kho pob txha, endochondral ossification mechanism, thiab txoj kev loj hlob ntawm kev tswj hwm. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₈₉H₁₄₃N₂₇O₂₈S₂ |
| Molecular Luj (Da) | 2164.40 |
| Hom qauv | Disulfide-bridged natriuretic peptide analog, ua kom zoo dua |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Ntev (aa) |
| Vosoritide | Vosoritide; CNP analog; Achondroplasia kho peptide | Txhawb txoj kev loj hlob ntawm cov pob txha ntev, Endochondral ossification, High NPR -B selectivity, Achondroplasia txoj kev tshawb fawb, Kev loj hlob regulatory peptide, Skeletal txoj kev loj hlob | Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-As p-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys (Disulfide txuas) | C₈₉H₁₄₃N₂₇O₂₈S₂ | 2163.02 | 2164.4 | Intramolecular disulfide choj | 22 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-VOS001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted. ** txwv tsis pub muaj zog los txo cov neeg ua hauj lwm ** | ruaj khov rau 2 lub lis piam ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 48h ntawm 4 degree; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Disulfide daim ntawv cog lus rhiab rau cov muaj zog txo cov neeg ua haujlwm thiab nquag ua kom tawg thiab tsis ua haujlwm. Native peptide yooj yim degraded los ntawm nruab nrab endopeptidase | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-VOS001 | Kev xaiv ntau NPR-B agonist uas txhawb nqa chondrocyte proliferation/differentiation thiab txhawb nqa cov pob txha ntev kom txhim kho achondroplasia | Vosoritide yog ib ntus -optimized C-type natriuretic peptide (CNP) analog. Nws khaws cov core receptor-binding nplhaib qauv ntawm haiv neeg CNP thaum optimizing davhlau ya nyob twg ua ke los txhim kho metabolic stability. Nws khi nrog qhov tshwj xeeb thiab kev sib raug zoo rau natriuretic peptide receptor B (NPR-B) ntawm chondrocytes ntawm cov pob txha loj hlob phaj, ua kom cov intracellular guanylate cyclase domain ntawm receptor, elevates cGMP theem, thiab pib downstream signaling txoj hauv kev los txhawb kev loj hlob, kev sib txawv ntawm kev loj hlob thiab kev loj hlob ntawm cov phaj. endochondral ossification, thiab yog li txhawb nqa longitudinal loj hlob ntawm cov pob txha ntev. Tsis zoo li atrial natriuretic peptide thiab lub paj hlwb natriuretic peptide, nws yuav luag tsis muaj kev cuam tshuam rau NPR-A receptors, tsis muaj kev cuam tshuam rau cov hlab plawv xws li hypotension thiab diuresis, thiab muaj zog pob txha loj hlob xaiv. | Achondroplasia txoj kev kawm, Skeletal txoj kev loj hlob biology, Kev loj hlob phaj kev cai, Endochondral ossification mechanism, Natriuretic peptide txoj kev kawm, Tsis tshua muaj kab mob tshuaj kev loj hlob | Natriuretic Peptide Receptor B (NPR-B/NPR2); cGMP-kev sib haum xeeb chondrocyte kev sib txawv; Endochondral ossification txoj kev ntawm cov pob txha loj hlob phaj ntev |
Cim npe nrov: CAS 1480724-61-5 vosoritide, Tuam Tshoj cas 1480724-61-5 vosoritide manufacturers, lwm tus, Hoobkas
