Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 2459531-73-6: ecnoglutide (xw003) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 2459531-73-6: ecnoglutide (xw003) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
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| Khoom npe | CAS: 2459531-73-6: Ecnoglutide (XW003) |
| Kev piav qhia | Ecnoglutide yog ib tug tshiab - tiam ntev - ua cAMP-biased glucagon-zoo li peptide-1 (GLP-1) receptor agonist. Nws khi rau GLP-1 receptors nrog siab affinity, xaiv activates downstream Gs-cAMP signaling pathway, potently txhawb qabzib{13}}nyob ntawm cov insulin secretion, inhibits glucagon tso tawm, qeeb plab hnyuv plab thiab txo qab los noj mov, exerting tseem ceeb cov piam thaj 5{1} - Hloov kho los ntawm qhov chaw- tshwj xeeb amino acid kev hloov pauv thiab fatty acid sab saw, nws tau ua kom zoo dua peptidase tsis kam thiab ua kom ntev hauv vivo ib nrab-lub neej, txhawb kev tswj hwm ib lub lim tiam. Lub caij no, vim yog kev ua kom tsis zoo ntawm cAMP txoj hauv kev, -arrestin recruitment thiab receptor internalization tau txo qis nrog kev ua kom zoo dua. Nws induces koob tshuaj-dependant glycemic txhim kho thiab lub cev yuag txo nyob rau hauv cov ntshav qab zib rog tsiaj qauv, thiab yog ib tug tseem ceeb cov cuab yeej peptide rau kev tshawb fawb mechanism ntawm metabolic kab mob xws li hom 2 mob ntshav qab zib thiab rog, nrog rau cov tshuaj peptide kev loj hlob. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb peptide molecular mis | C₁₉₄H₃₀₄N₄₈O₆₁ |
| Dawb peptide molecular hnyav (Da) | 4284.76, siab dua rau daim ntawv ntsev |
| Hom qauv | Linear modified peptide, fatty acid side chain modification, muaj unnatural linker, dawb peptide / acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Ecnoglutide | xwv 003 | GLP-1 receptor agonist, cAMP signaling-kev tsis ncaj ncees, kev ua haujlwm ntev ntawm cov piam thaj txo qis & poob phaus, kev tswj hwm cov metabolism | Ntev- ua yeeb yam hloov kho peptide optimized raws li GLP-1 qaum; Ala8 →Val txhim kho DPP-4 tsis kam; Lys30 yog conjugated nrog C18 fatty diacid sab saw ntawm -glutamic acid + dual AEEA linkers; cAMP-biased activation txo -arrestin recruitment thiab receptor internalization | Dawb puag: C₁₉₄H₃₀₄N₄₈O₆₁; Daim ntawv ntsev: C₁₉₄H₃₀₄N₄₈O₆₁·xC₂H₄O₂ | 4282.22 | 4284.76 | Dawb peptide / acetate | 31 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-ECN001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, hauv qab cua nitrogen. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 2 xyoos ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau luv luv -lub sij hawm shipping ntawm ambient kub, haum rau chav tsev kub logistics. | ruaj khov rau 7 hnub ntawm 4 degree. Solubility: ~ 100 mg / mL hauv DMSO (yuav tsum tau sonication); me ntsis soluble hauv dej ntshiab. Npaj aqueous tov los ntawm serial dilution los ntawm DMSO Tshuag. Fatty acid sab saw nyhav ua rau peptide aggregation; zam rov qab khov -thaw. | ruaj khov rau 3 xyoos ntawm -20℃thiab 2 xyoos ntawm 4 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ECN001 | cAMP-txoj cai ntev- ua haujlwm GLP-1 receptor agonist nrog cov piam thaj ua ke- txo qis thiab poob phaus | Ecnoglutide yog ib tug tshiab - tiam ntev - ua cAMP-biased glucagon-zoo li peptide-1 (GLP-1) receptor agonist. Nws khi rau GLP-1 receptors nrog siab affinity, xaiv activates downstream Gs-cAMP signaling pathway, potently txhawb qabzib{13}}nyob ntawm cov insulin secretion, inhibits glucagon tso tawm, qeeb plab hnyuv plab thiab txo qab los noj mov, exerting tseem ceeb cov piam thaj 5{1} - Hloov kho los ntawm qhov chaw- tshwj xeeb amino acid kev hloov pauv thiab fatty acid sab saw, nws tau ua kom zoo dua peptidase tsis kam thiab ua kom ntev hauv vivo ib nrab-lub neej, txhawb kev tswj hwm ib lub lim tiam. Lub caij no, vim yog kev ua kom tsis zoo ntawm cAMP txoj hauv kev, -arrestin recruitment thiab receptor internalization tau txo qis nrog kev ua kom zoo dua. Nws induces koob tshuaj-dependant glycemic txhim kho thiab lub cev yuag txo nyob rau hauv cov ntshav qab zib rog tsiaj qauv, thiab yog ib tug tseem ceeb cov cuab yeej peptide rau kev tshawb fawb mechanism ntawm metabolic kab mob xws li hom 2 mob ntshav qab zib thiab rog, nrog rau cov tshuaj peptide kev loj hlob. | Hom 2 mob ntshav qab zib mellitus mechanism kev tshawb fawb, kev tshawb fawb kev rog, kev tshawb fawb metabolic syndrome, GLP-1 receptor biased signaling research, metabolic peptide tshuaj txhim kho | Glucagon-zoo li peptide 1 receptor (GLP-1R); Gs-cAMP teeb liab txoj hauv kev; Kev cai GPCR teeb liab kev cai |
Cim npe nrov: CAS: 2459531-73-6: ecnoglutide (xw003), Tuam Tshoj cas: 2459531-73-6: ecnoglutide (xw003) manufacturers, lwm tus neeg, Hoobkas
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