Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 159768-75-9: lobradimil (rmp-7) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 159768-75-9: lobradimil (rmp-7) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 159768-75-9: Lobradimil (RMP-7) |
| Kev piav qhia | Lobradimil yog ib qho kev xaiv zoo heev bradykinin B2 receptor agonist. Nws tshwj xeeb khi rau B2 receptors ntawm cerebral microvascular endothelial hlwb, ib ntus thiab thim rov qab qhib nruj junctions ntawm cov ntshav- hlwb teeb meem, txhim kho intracerebral kev ua tau zoo ntawm cov tshuaj chemotherapeutic thiab macromolecules, nrog tsawg kawg nkaus ntawm cov ntshav siab. Hauv cov kab mob hauv nruab nrab ntawm cov paj hlwb xws li glioblastoma thiab lub hlwb metastasis, nws ua rau kom lub hlwb muaj zog thiab kho tau zoo ntawm co- tswj cov tshuaj antitumor. Nws yog ib qho cuab yeej classic peptide rau cov ntshav-b hlwb barrier tswj mechanism kev tshawb fawb thiab hlwb qog cov tshuaj xa mus tshawb fawb. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb puag molecular mis | C₅₀H₇₃N₁₅O₁₁ |
| Dawb puag molecular hnyav (Da) | 1072.22, siab dua rau daim ntawv ntsev |
| Hom qauv | Linear modified nonapeptide, bradykinin analog, dawb peptide / acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Lobradimil | Lobradimil; RMP-7 | Kev xaiv siab heev bradykinin B2 receptor agonist, thim rov qab cov ntshav - lub paj hlwb thaiv kev qhib, txhim kho lub hlwb xa tshuaj | Bradykinin structural analog, linear hloov nonapeptide, xaiv khi rau B2 receptors ntawm cerebral vascular endothelium, ib ntus thiab reversibly qhib cov ntshav- lub hlwb barrier nruj junctions nrog tsawg kawg nkaus ntawm cov ntshav siab. | Dawb peptide: C₅₀H₇₃N₁₅O₁₁ | 1071.56 | 1072.22 | Dawb peptide / acetate | 9 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-LOB001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | Nyob ruaj khov rau 14 hnub ntawm 4 degree. Dawb soluble hauv dej, dilute acetic acid thiab physiological buffers. Aqueous tov yog raug rau peptidase degradation; aliquot sterilely thiab khov tom qab reconstitution. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-LOB001 | Selective B2 receptor agonist reversibly qhib cov ntshav -b hlwb barrier los txhim kho lub hlwb xa tshuaj | Lobradimil (RMP-7) yog ib qho kev xaiv zoo heev ntawm bradykinin B2 receptor agonist. Nws tshwj xeeb khi rau B2 receptors ntawm cerebral microvascular endothelial hlwb, transiently thiab reversibly qhib nruj junctions ntawm cov ntshav- hlwb barrier, ho txhim khu intracerebral xa efficiency ntawm chemotherapeutic tshuaj, peptides thiab macromolecules, nrog tsawg kawg nkaus kev nyab xeeb ntawm cov ntshav siab. Hauv cov kab mob hauv nruab nrab ntawm cov paj hlwb xws li glioblastoma thiab lub hlwb metastasis, nws ua rau kom lub hlwb muaj zog thiab kho tau zoo ntawm co- tswj cov tshuaj antitumor. Nws yog ib qho cuab yeej classic peptide rau cov ntshav-hlwb thaiv kev tswj hwm kev tshawb fawb thiab kev tshawb fawb ntawm cov qog hlwb. | Ntshav-Kev tshawb fawb txog kev tswj lub hlwb, kev tshawb fawb hauv hlwb qog nqaij hlav, kev tshawb fawb glioblastoma, kev tshawb fawb txog kev ua haujlwm ntawm bradykinin receptor, hauv nruab nrab paj hlwb kev loj hlob technology | Bradykinin B2 receptor (BDKRB2); Ntshav-b hlwb barrier nruj hlws ris txoj cai txoj kev |
Cim npe nrov: cas:159768-75-9: lobradimil (rmp-7), Tuam Tshoj cas:159768-75-9: lobradimil (rmp-7) manufacturers, lwm tus neeg, Hoobkas
