Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 2269511-95-5 anrikefon (dawb puag) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 2269511-95-5 anrikefon (dawb puag) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 2269511-95-5: Anrikefon (Dawb puag) |
| Kev loj hlob code | HSK21542, ib qho kev xaiv zoo tshaj plaws nyob rau hauv - txwv tsis pub kappa opioid receptor agonist nrog tag nrho -D-amino acid qaum rau kev txhim kho metabolic stability thiab tsis muaj ntshav qab zib- lub hlwb thaiv kev nkag mus. Siv rau hauv kev ua xua tom qab phais, CKD- koom nrog kev ua xua thiab tsis yog- kev tshawb fawb txog kev ua xua tshuaj lom. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₃₉H₅₇N₇O₆ |
| Molecular Luj (Da) | 723.92 |
| Daim ntawv ntsev | Dawb puag |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Anrikefon | Anrikefon dawb puag; HSK21542 dawb puag; CAS 2269511-95-5; Peripheral KOR agonist | Peripheral kappa opioid receptor agonist, Analgesic & antipruritic, Postoperative mob tshawb fawb, CKD pruritus kev tshawb fawb, Tsis yog -central opioid, Tsawg kev pheej hmoo | D-Phenylalanine-D-phenylalanine-D-leucine-D-lysine-2-acetyl-2,7-diazaspiro[3.5]nonane, all-blinkone acid | C₃₉H₅₇N₇O₆ (dawb puag) | 723.43 | 723.92 | Dawb amine, tag nrho -D-amino acid configuration | Amide - txuas spiro nplhaib, tsis muaj carboxyl dawb | 4 (tub ntxhais peptide qaum qaum nrog qhov tsis zoo spiro terminus) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEP-ANR-F001 | hmoov dawb | Khoom hmoov: khaws cia ntawm -20 degree, tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam rov qab khov-thaw cycles | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; Cov kev daws teeb meem pom zoo kom npaj rau hauv dilute acetic acid lossis DMSO | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 6 lub hlis ntawm -80℃hauv aliquots; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej tsis zoo solubility, me ntsis soluble hauv dej **. Dissolve nyob rau hauv dilute acetic acid, DMSO los yog methanol. Tsis txhob muaj cov kua qaub / puag ncig kom tiv thaiv amide bond hydrolysis | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEP-ANR-F001 | Highly xaiv peripheral KOR agonist nyob rau hauv daim ntawv dawb dawb uas tsis muaj cov kev mob tshwm sim hauv nruab nrab, siv hauv kev ua haujlwm tom qab analgesia thiab CKD pruritus mechanism tshawb fawb | Anrikefon (txoj kev loj hlob code HSK21542) yog ib qho kev xaiv zoo heev peripherally - txwv kappa opioid receptor (KOR) agonist. Nws cov pob txha caj qaum yog peptide derivative nrog 4 D-amino acids, conjugated nrog 2-acetyl diazaspiro nplhaib ntawm C-terminus los txhim kho receptor affinity thiab peripheral selectivity, nrog negligible ntshav-brain barri. Nws khi nrog kev xaiv siab rau KOR hauv cov ntaub so ntswg peripheral, inhibits peripheral kis ntawm qhov mob thiab khaus, thiab ua kom muaj zog analgesic thiab antipruritic teebmeem. Nrog tsis tshua muaj affinity rau μ thiab δ opioid receptors, nws zam kev quav tshuaj, ua pa nyuaj siab, cem quav thiab xeev siab ntawm cov tshuaj hauv nruab nrab opioids. Lub hauv paus pub dawb yog cov tshuaj siv tshuaj, tsim nyog rau kev tsim kho, tshuaj ntsev daim ntawv tshuaj ntsuam xyuas thiab kev tshawb fawb tshuaj pharmacological, thiab ua haujlwm ua cov cuab yeej tseem ceeb molecule rau qhov mob thiab pruritus mechanism kev tshawb fawb thiab kev txhim kho tshiab uas tsis yog tshuaj tua kab mob. | Kev tshawb fawb tshuaj kho mob, Kev tshawb fawb tom qab phais mob, kev tshawb fawb CKD pruritus, Opioid receptor txoj kev tshawb fawb, Tsis yog -kev txhim kho kev mob ntshav qab zib, Peripheral paj hlwb kev tshawb fawb | Kappa Opioid Receptor (KOR); Peripheral nociceptive signaling txoj kev; Khaub thuas signaling txoj kev |
Cim npe nrov: CAS 2269511-95-5 anrikefon (dawb puag), Tuam Tshoj cas 2269511-95-5 anrikefon (dawb puag) manufacturers, lwm tus neeg, Hoobkas
