Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 2296814-85-0: dapiglutide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 2296814-85-0: dapiglutide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 2296814-85-0: Dapiglutide |
| Kev piav qhia | Dapiglutide yog ib tug tshiab - tiam ntev - ua yeeb yam dual agonist ntawm GLP-1 receptor thiab glucagon receptor. Nws ua kom muaj txiaj ntsig zoo rau ob qho tib si metabolic receptors thiab synergistically drives downstream cAMP signaling txoj kev: exerts qabzib -nyob ntawm cov insulin secretion, gastric emptying inhibition thiab noj zaub mov kom tsawg ntawm GLP-1 txoj kev; nce basal zog siv, txhawb lipolysis thiab hepatic lipid metabolism los ntawm txoj kev glucagon, ua tiav ntau yam metabolic cov txiaj ntsig ntawm cov piam thaj txo qis, poob phaus thiab txhim kho hepatic steatosis. Hloov kho nrog fatty acid sab chains, nws tau txhim kho peptidase tsis kam thiab ua kom ntev hauv vivo ib nrab-lub neej, txhawb kev ncua sijhawm ntev. Nws nthuav tawm cov tshuaj pharmacological zoo heev hauv cov qauv ntawm kev rog rog, ntshav qab zib hom 2 thiab tsis muaj cawv steatohepatitis, thiab yog cov cuab yeej tseem ceeb peptide rau kev tshawb nrhiav kab mob metabolic thiab kev txhim kho tshuaj peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb puag molecular mis | C₁₈₇H₂₉₁N₄₅O₅₈ |
| Dawb puag molecular hnyav (Da) | 4156.6, siab dua rau daim ntawv ntsev |
| Hom qauv | Linear hloov peptide nrog fatty acid sab saw hloov kho, dawb peptide / acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Dapiglutide | Dapiglutide | GLP-1R/GCGR dual receptor agonist, ua haujlwm ntev cov piam thaj txo qis & poob phaus, nce kev siv zog | Ntev - ua yeeb yam hloov peptide; fatty acid side chain modifications prolongs in vivo ib nrab-lub neej; balancedly activates GLP-1 thiab glucagon receptors los ua ke tswj cov piam thaj-lipid metabolism thiab lub zog homeostasis | Dawb puag: C₁₈₇H₂₉₁N₄₅O₅₈ | 4154.12 | 4156.6 | Dawb peptide / acetate | 39 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-DAP001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, hauv qab cua nitrogen. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 2 xyoos ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau luv luv -lub sij hawm shipping ntawm ambient kub, haum rau chav tsev kub logistics. | ruaj khov rau 7 hnub ntawm 4 degree. Solubility: ~ 100 mg / mL hauv DMSO (yuav tsum tau sonication); me ntsis soluble hauv dej ntshiab. Npaj aqueous tov los ntawm serial dilution los ntawm DMSO Tshuag. Fatty acid sab saw nyhav ua rau peptide aggregation; zam rov qab khov -thaw. | ruaj khov rau 3 xyoos ntawm -20℃thiab 2 xyoos ntawm 4 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DAP001 | Ntev - ua yeeb yam GLP-1 / glucagon dual receptor agonist nrog synergistic qabzib txo qis, poob phaus thiab tswj lipid | Dapiglutide yog ib tug tshiab - tiam ntev - ua yeeb yam dual agonist ntawm GLP-1 receptor thiab glucagon receptor. Nws ua kom muaj txiaj ntsig zoo rau ob qho tib si metabolic receptors thiab synergistically drives downstream cAMP signaling txoj kev: exerts qabzib -nyob ntawm cov insulin secretion, gastric emptying inhibition thiab noj zaub mov kom tsawg ntawm GLP-1 txoj kev; nce basal zog siv, txhawb lipolysis thiab hepatic lipid metabolism los ntawm txoj kev glucagon, ua tiav ntau yam metabolic cov txiaj ntsig ntawm cov piam thaj txo qis, poob phaus thiab txhim kho hepatic steatosis. Hloov kho nrog fatty acid sab chains, nws tau txhim kho peptidase tsis kam thiab ua kom ntev hauv vivo ib nrab-lub neej, txhawb kev ncua sijhawm ntev. Nws nthuav tawm cov tshuaj pharmacological zoo heev hauv cov qauv ntawm kev rog rog, ntshav qab zib hom 2 thiab tsis muaj cawv steatohepatitis, thiab yog cov cuab yeej tseem ceeb peptide rau kev tshawb nrhiav kab mob metabolic thiab kev txhim kho tshuaj peptide. | Kev tshawb fawb txog kev rog rog, kev tshawb fawb txog ntshav qab zib hom 2, tsis yog -kev tshawb nrhiav dej cawv steatohepatitis, kev tshawb fawb metabolic syndrome, kev txhim kho tshuaj metabolic peptide | Glucagon-zoo li peptide 1 receptor (GLP-1R); Glucagon receptor (GCGR); cAMP signaling txoj kev |
Cim npe nrov: cas:2296814-85-0: dapiglutide, Tuam Tshoj cas:2296814-85-0: dapiglutide manufacturers, lwm tus neeg, Hoobkas
