Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 286942-97-0 ezatiostat hydrochloride hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 286942-97-0 ezatiostat hydrochloride los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | Tom ntej: Ezatiostat Hydrochloride CAS 286942-97-0 |
| Tshuaj npe | Ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate hydrochloride |
| Purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₂₇H₃₆ClN₃O₆S |
| Molecular Luj (Da) | 566.11 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | Cov khoom vaj khoom tsev | Daim ntawv ntsev |
| Ezatiostat hydrochloride | Ezatiostat HCl; TLK199; TER199; Telintra; CAS Nr .: 286942-97-0 | GSTP1 inhibitor, Hematopoietic progenitor proliferation, MDS tshawb fawb, Glutathione analog, Prodrug, Antitumor adjuvant | Glutathione tripeptide analog (Glu-Cys- -phenylglycine qaum, diethyl ester prodrug, benzylthio hloov kho) | C₂₇H₃₆ClN₃O₆S | 565.2 | 566.11 | Me me molecule peptide analog prodrug | Hydrochloride |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| SM-EZA001 | Dawb hmoov | Khaws ntawm -20 degree, tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam rov qab khov-thaw cycles thiab ya raws | Khoom hmoov ruaj khov rau 2 xyoos kaw thiab qhuav ntawm 2-8 degree; DMSO cov kev daws teeb meem ruaj khov rau 1 lub hlis ntawm -20 degree, 6 lub hlis ntawm -80℃tom qab aliquoting | DMSO daws ruaj khov rau 72 h ntawm 4 degree; aqueous tov yog ester hydrolysis, npaj freshly ua ntej siv | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Hom phiaj / Receptor |
| SM-EZA001 | Qhov ncauj nquag glutathione analog prodrug, xaiv GSTP1-1 inhibitor; activates JNK / MAPK txoj hauv kev, txhawb nqa ntau hom kab sib txawv ntawm hematopoietic progenitors, siv hauv MDS thiab kev tshawb fawb cytopenia | Ezatiostat hydrochloride (txoj kev loj hlob code TLK199) yog ib qho kev ua haujlwm ntawm qhov ncauj glutathione tripeptide analog prodrug thiab ib qho kev xaiv inhibitor ntawm glutathione S-transferase P1-1 (GSTP1-1). Tom qab nkag mus rau hauv cov hlwb, nws nkag mus rau esterase{10}}mediated de-esterification thiab hloov mus rau hauv daim ntawv nquag TLK117, uas tshwj xeeb khi rau GSTP1-1 thiab inhibits nws cov enzymatic kev ua si, tshem tawm cov kev cai tsis zoo ntawm GSTP1-1 ntawm c-Jun N-terminal kinase kinese activation, signaling cascades. Nws txhawb kev loj hlob thiab ntau hom kab sib txawv ntawm cov pob txha pob txha hematopoietic progenitors, txhim kho cov khoom ntawm granulocytes, monocytes, erythrocytes thiab platelets, thiab ameliorates cytopenia txuam nrog myelodysplastic syndromes (MDS). Nws kuj induces apoptosis nyob rau hauv leukemia hlwb thiab sensitizes qog hlwb rau chemotherapeutic agents. Qhov kev sib xyaw no tau ua tiav theem II kev sim tshuaj rau MDS, thiab ua haujlwm tseem ceeb ntawm cov cuab yeej siv rau hematology, qog tshuaj kho mob thiab kev tshawb fawb txog hematopoietic mechanism. | Hematological pharmacology tshawb fawb, Myelodysplastic syndrome kev tshawb fawb, qog tshuaj tiv thaiv kev tshawb fawb, Glutathione txoj kev tshawb fawb, Hematopoietic kev cai tshawb fawb, me me molecule prodrug kev loj hlob | Glutathione S-transferase P1-1 (GSTP1-1); JNK/MAPK signaling pathway |
Cim npe nrov: CAS 286942-97-0 ezatiostat hydrochloride, Tuam Tshoj cas 286942-97-0 ezatiostat hydrochloride manufacturers, lwm tus neeg, Hoobkas
