Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 460738-38-9 ecallantide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 460738-38-9 ecallantide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | Tom ntej: Ecallantide CAS 460738-38-9 |
| Ib ntus | Thr-Asp-Ph-Cys-Asn-Leu-Pro-Pro-Tyr- Thr-Gly-Pro-Cys-Val-Ala-Ph-Ph-A sp-Ile-Ala-Gly-Lys-Cys-Gln-Phe-L ys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Ph e-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gl y-Arg-Gly-Asn-Asn-Ph-Val-Tyr-Gl y-Gly-Cys-Asp-Arg-Pro-Asn-Thr-Se r-Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys (Disulfide txuas: Cys4-Cys52, Cys13-Cys38, Cys23-Cys59) |
| Peb tsab ntawv ib ntus | H-Thr-Asp-Ph-Cys-Asn-Leu-Pro-Pro-Tyr{-Thr-Gly-Pro-Cys-Val-Ala-Ph-Phe{17 }}Asp-Ile-Ala-Gly-Lys-Cys-Gln-Phe- Lys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Ph e-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gly{-Arg-Gly-Asn-Asn-Phe-Val-Tyr-Gly{{5 0}}Gly-Cys-Asp-Arg-Pro-Asn-Thr-Ser{{58} }Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys-OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₃₀₈H₄₇₈N₈₆O₉₄S₆ |
| Molecular Luj (Da) | 7059.97 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Ecallantide | Ecallantide; DX-88; Kalbitor; CAS Nr .: 460738-38-9; Plasma kallikrein inhibitor | Plasma kallikrein inhibitor, Bradykinin ntau lawm inhibition, kev kho mob ntshav qab zib angioedema, Serine protease inhibitor, Kev tshawb nrhiav kab mob | Thr-Asp-Ph-Cys-Asn-Leu-Pro-Pro-Tyr- Thr-Gly-Pro-Cys-Val-Ala-Ph-Ph-A sp-Ile-Ala-Gly-Lys-Cys-Gln-Phe-L ys-Tyr-Asn-Gly-Glu-Gln-Asn-Arg-Ph e-Tyr-Ser-Ala-Trp-Gly-Cys-Asp-Gl y-Arg-Gly-Asn-Asn-Ph-Val-Tyr-Gl y-Gly-Cys-Asp-Arg-Pro-Asn-Thr-Se r-Glu-Glu-Cys-Leu-Arg-Thr-Ala-Cys (3 disulfide txuas rau globular conformation) | C₃₀₈H₄₇₈N₈₆O₉₄S₆ | 7055.42 | 7059.97 | Dawb amine, unmodified | Dawb carboxyl, unmodified | 60 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ECA001 | hmoov dawb | Khaws ntawm -20 degree, tiv thaiv lub teeb, kaw thiab qhuav, aliquoted; tsis txhob rov qab khov-thaw cycles thiab txo cov neeg ua haujlwm | Khoom hmoov ruaj khov rau 2 xyoos kaw thiab qhuav ntawm 2-8 degree; npaj aqueous daws freshly ua ntej siv, aliquots ruaj khov rau 1 lub hlis ntawm -20 degree | ruaj khov rau 72 h ntawm 4 degree; disulfide bonds rhiab heev rau txo cov neeg ua hauj lwm thiab kub siab, tsis txhob ncua chav tsev kub raug | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Hom phiaj / Receptor |
| PEB-ECA001 | Muaj kev xaiv thim rov qab ntshav plasma kallikrein inhibitor uas thaiv bradykinin ntau lawm, siv rau hauv keeb kwm angioedema nres thiab kev tshawb fawb txog kev mob. | Ecallantide (kev loj hlob code DX-88) yog lub zog, xaiv cov ntshav kallikrein inhibitor tsim los ntawm Kunitz-hom serine protease inhibitor scaffold. Nws compact globular qauv precisely haum rau lub active hnab tshos ntawm plasma kallikrein, sib tw inhibiting lub cleavage ntawm siab -molecular- hnyav kininogen thiab txo bradykinin tiam ntawm qhov chaw. Bradykinin yog tus neeg nruab nrab ntawm kev nce vascular permeability, cov ntaub so ntswg edema, mob thiab inflammatory teb, yog li Ecallantide zoo relieves mob edematous tawm tsam nyob rau hauv cov neeg mob uas hereditary angioedema (HAE). Piv nrog rau C1 esterase inhibitor hloov kho, nws muaj lub hom phiaj ncaj qha, qhov hnyav dua molecular, cov ntaub so ntswg muaj zog dua, thiab tsis cuam tshuam nrog lwm txoj hauv kev coagulation cascade. Pom zoo los ntawm FDA rau mob HAE tawm tsam, nws ua haujlwm ua cov cuab yeej tseem ceeb molecule rau inflammatory pharmacology, kallikrein-kinin system tshawb fawb thiab peptide enzyme inhibitor tshuaj txhim kho. | Inflammation Pharmaology tshawb fawb, Kev tshawb fawb keeb kwm angioedema, Kallikrein -kinin system kev tshawb fawb, Peptide enzyme inhibitor kev loj hlob, vascular permeability kev tshawb fawb | Plasma kab mob; Bradykinin ntau lawm txoj kev |
Cim npe nrov: CAS 460738-38-9 ecallantide, Tuam Tshoj cas 460738-38-9 ecallantide manufacturers, lwm tus, Hoobkas
