Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm cas380449-51-4 melflufen hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas380449-51-4 melflufen los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS 380449-51-4 Melflufen |
| Tshuaj npe | Ethyl (2S)-2-[[(2S)-3-[4-[bis(2-chloroethyl)amino]phenyl]-2-aminopropanoyl]amino]-3-(4-fluorophenyl)propanoate |
| Peb tsab ntawv ib ntus | H-Melphalan-Phe(4-F)-OEt |
| Purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₂₈H₃₀Cl₂FN₃O₄ |
| Molecular Luj (Da) | 566.46 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Melflufen | Melphalan flufenamide; Pepaxto; CAS 380449-51-4; Peptide-conjugated alkylating tus neeg sawv cev | Peptide-tshuaj conjugate, DNA alkylating tus neeg saib xyuas, Kev kho ntau yam myeloma, Antitumor cytotoxicity, Tshuaj-cov tshuaj tiv thaiv qog | 4-Bis(2-}chloroethyl)amino-L-phenylalanine-L-4-fluorophenylalanine (C-terminal ethyl ester) | C₂₈H₃₀Cl₂FN₃O₄ | 565.16 | 566.46 | Bis (2-chloroethyl) amino hloov kho ntawm phenyl nplhaib | Kev hloov kho ethyl ester | 2 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PDC-MEL001 | hmoov dawb | Khaws ntawm -20℃, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam rov qab khov-thaw cycles thiab ya raws | Khoom hmoov ruaj khov rau 2 xyoos kaw thiab qhuav ntawm 2-8 degree; DMSO cov kev daws teeb meem ruaj khov rau 1 lub hlis ntawm -20℃hauv qhov tsaus ntuj | DMSO daws ruaj khov rau 72 h ntawm 4 degree; nitrogen mustard pawg thiab ester daim ntawv cog lus yog nquag hydrolysis nyob rau hauv aqueous tov, npaj freshly ua ntej siv | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Hom phiaj / Receptor |
| PDC-MEL001 | Aminopeptidase-activated peptide-conjugated alkylating tus neeg sawv cev nrog cov qog ntshav siab- xaiv cytotoxicity, siv nyob rau hauv relapsed / refractory ntau myeloma thiab tshuaj-cov tshuaj tiv thaiv qog nqaij hlav | Melflufen (lub npe npe Pepaxto) yog thawj zaug pom zoo peptide-tshuaj conjugate (PDC) alkylating tus neeg sawv cev, suav nrog melphalan nquag moiety txuas rau L-4-fluorophenylalanine ethyl ester ntawm peptide daim ntawv cog lus. Nws yog hydrolyzed sai heev los ntawm aminopeptidases heev nthuav tawm ntawm qog hlwb, xaiv tso tawm siab concentrations active melphalan nyob rau hauv cov qog hlwb. Cov bis (2-chloroethyl) amino pawg alkylates DNA bases, inducing DNA interstrand crosslinks thiab ob-strand so, ua rau cell voj voog ntes thiab qog cell apoptosis. Piv nrog rau cov pa melphalan, nws ua tiav cov qog ua kom zoo dua qub thiab qis dua cov kab mob toxicity, thiab khaws cytotoxicity tawm tsam ntau lub hlwb myeloma resistant rau proteasome inhibitors thiab cov tshuaj immunomodulatory. Clinically pom zoo rau relapsed / refractory ntau myeloma, nws ua hauj lwm raws li ib tug tseem ceeb cov cuab yeej molecule rau hematological oncology pharmacology, tshuaj tiv thaiv mechanism kev tshawb fawb thiab peptide-drug conjugate txoj kev loj hlob. | Kev tshawb fawb hematological oncology, Kev tshawb fawb ntau yam myeloma, Tshuaj -kev tshawb fawb qog nqaij hlav, Peptide- tshuaj conjugate kev txhim kho, DNA puas kho kev tshawb fawb tshawb fawb | DNA alkylation puas; Apoptosis txoj kev; Aminopeptidase- tau txais cov tshuaj |
Cim npe nrov: CAS 380449-51-4 melflufen, Tuam Tshoj cas380449-51-4 melflufen manufacturers, lwm tus, Hoobkas
