Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm pnc-28 acetate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo pnc-28 acetate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | PNC-28 acetate hmoov |
| Kev piav qhia | PNC-28 yog ib tug tshiab-tiam bifunctional anti-tumor peptide nrog ob qho tib si cell-nkaum peev xwm thiab p53 txoj kev ua kom muaj zog. Nws muaj cov tub ntxhais MDM2-binding peptide ntu ntawm p53 protein, uas sib tw khi MDM2 protein, blocks MDM2-mediated p53 ubiquitination thiab degradation, stabilizes thiab activates endogenous p53 txoj kev, thiab induces qog cell voj voog ntes thiab apoptosis. Meanwhile, nws yog fused nrog ib tug xov tooj ntawm kev nkag mus rau ib theem zuj zus thiab tuaj yeem nkag mus rau cov qog hlwb zoo yam tsis muaj cov tshuaj hloov pauv. Nws nthuav tawm qhov tseem ceeb ntawm kev loj hlob inhibition thiab kev ua haujlwm pro-apoptotic tawm tsam p53 cov qog nqaij tsiaj qus uas muaj cov tshuaj lom tsis zoo rau cov hlwb ib txwm muaj. Siv rau hauv kev tshawb fawb qog nqaij hlav thiab tsom rau kev txhim kho qog nqaij hlav peptide. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular hnyav (Da) | ~ 3200 (raws li qhov tseeb hluavtaws batch) |
| Hom qauv | Fusion ua haujlwm peptide, acetate daim ntawv |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| PNC-28 acetate hmoov | PNC-28 acetate; p53 ua kom peptide | p53 txoj kev ua kom, MDM2 binding blockade, Cell- nkag peptide, Tiv thaiv - qog proliferation, Pro-apoptotic, Targeted peptide | Fusion peptide qaum nrog N-terminal penetrating cheeb tsam + C-terminal p53 khi cheeb tsam | Loj fusion peptide, raws li qhov tseeb batch MS | - | ~ 3200 (theoretical) | Acetate | 28 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-PNC2801 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 7 hnub ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. nplua nuj nyob rau hauv cov amino acids yooj yim, zoo them, muaj zog cell penetrability | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PNC2801 | Bifunctional cell- nkag mus rau p53 activating peptide uas autonomously nkag mus rau cov qog hlwb, thaiv MDM2-p53 khi thiab induces qog apoptosis | PNC-28 exerts anti- qog cov nyhuv los ntawm kev sib koom ua ke ntawm ob lub luag haujlwm ua haujlwm: lub xovtooj ntawm tes- nkag mus rau lub peptide hla cov qog cell membranes zoo thiab nkag mus rau cytoplasm yam tsis muaj kev hloov pauv ntxiv; lub p53-binding domain mimics N-terminal binding sequence ntawm p53, khi lub hnab ntim hydrophobic ntawm MDM2 nrog kev sib raug zoo siab, kev sib tw thaiv kev sib cuam tshuam ntawm endogenous p53 thiab MDM2, inhibits p53 ubiquitination thiab degradation, elevates nws cov kev ua haujlwm hauv qib intracellular ntxiv. Lub hom phiaj cov noob xws li p21 thiab Bax, thiab induces G1 cell voj voog ntes thiab mitochondrial apoptosis txoj kev ua kom. Nws qhia tau hais tias muaj txiaj ntsig zoo ntawm p53 cov qog nqaij tsiaj qus, txwv cov nyhuv ntawm p53-null / mutant qog, thiab txo qis ntawm cov cell toxicity dua li cov tshuaj chemotherapeutic. | p53 txoj kev kawm, qog proliferation & apoptosis, Targeted anti- qog peptides, MDM2 inhibitors, Cell- nkag mus rau peptides, Tiv thaiv -mob tshuaj txhim kho | MDM2-p53 kev sib cuam tshuam; p53 qog suppressor txoj kev; Cell voj voog ntes thiab apoptosis induction txoj kev |
Cim npe nrov: Tuam Tshoj pnc-28 acetate manufacturers, lwm tus neeg, Hoobkas
