Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm tes activable -peptide (accp) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo activable cell -peptide (accp) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Activatable Cell-Penetrating Peptide (ACCP) yog ib chav kawm tshiab ntawm cov tsheb thauj khoom ntse, thawj zaug piav qhia los ntawm Roger Tsien lub chaw kuaj mob hauv xyoo 2004, tseem hu ua activatable protein transduction domains (APTDs). ACCP tau tsim los daws cov kev txwv tseem ceeb ntawm cov xovtooj ntawm ib txwm siv -peptides (CPPs) - lawv tsis muaj cov ntaub so ntswg xaiv. Cov pa CPPs (piv txwv li, TAT, polyarginine R9), vim lawv cov nqi zoo, tuaj yeem tsis yog -tshwj xeeb nkag mus rau cov cell membranes ntawm txhua hom ntawm tes, uas ua rau muaj kev faib tawm thoob plaws, cov qog nqaij hlav tsis zoo, thiab cov ntaub so ntswg toxicity siab. ACCP ua tiav cov xovtooj ntawm tes{11}}kev nkag mus rau kev ua kom muaj zog tshwj xeeb ntawm lub hom phiaj ntawm qhov chaw (xws li cov qog microenvironment) los ntawm "molecular hloov" mechanism, yog li txhim kho lub hom phiaj kev xa khoom thiab kev nyab xeeb. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| activable cell -peptide penetrating (ACCP) | Activatable cell -peptide nkag mus; ACCP enzyme- teb CPP | Kev kho mob ntawm tes nkag mus, qog microenvironment targeting, enzyme- teb tus me nyuam, xa tshuaj ntse | Shielding domain txuas rau ntawm tes -peptide ntu ntawm qhov chaw enzyme cleavage; Kev ua haujlwm nkag mus yog npog ntsej muag nyob rau hauv ib txwm muaj lub cev muaj zog, thiab ua haujlwm tom qab qog-cov enzymes tshwj xeeb tshem tawm cov ntaub thaiv npog hauv cov qog microenvironment | C₁₁₂H₁₈₅N₃₅O₂₇ | 2524.39 | ~2526.0 | Acetate | 22 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-ACCP01 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid thiab acidic buffers. Activatable cell- nkag mus rau peptide; Kev ua haujlwm nkag mus yog qhib los ntawm ib puag ncig acidic lossis enzymatic stimulation. Tsawg nkag mus rau hauv kev ua si thiab zoo stability ntawm nruab nrab physiological tej yam kev mob. Tsis txhob ua kom ntxov ntxov thaum khaws cia thiab tuav. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ACCP01 | ACCP activatable CPP ua rau enzyme- ua kom muaj kev xa khoom ntse hauv cov qog microenvironment | ACCP yog ib qho enzyme- teb cov xov tooj ntse- nkag mus rau peptide tsim los ntawm cov chaw tiv thaiv, qhov chaw enzyme cleavage thiab ntu CPP. Nyob rau hauv ib txwm physiological tej yam kev mob, lub shielding domain suppresses nkag mus rau hauv lub systemic toxicity. Nyob rau hauv cov qog microenvironment, qog- tshwj xeeb proteases cleave thiab tshem tawm cov shielding domain, activating cell nkag mus rau kev kho kom haum xeeb xaiv tshuaj uptake los ntawm qog hlwb. | Kev tsim kho tshuaj ntse ntse, qog microenvironment teb, enzyme- teb lub tshuab xa khoom, CPP thev naus laus zis, kev siv tshuab thev naus laus zis | qog microenvironment- tshwj xeeb protease; CPP transmembrane sau npe; enzyme cleavage activation site |
Cim npe nrov: activable cell-peptide (accp), Tuam Tshoj activable cell-peptide (accp) manufacturers, lwm tus neeg, Hoobkas
