Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1192864-27-9 coop hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1192864-27-9 coop los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | CooP (CAS: 1192864-27-9) yog 9-amino acid linear glioblastoma-targeting peptide nrog cov kab ke CGLSGLGVA, txheeb xyuas los ntawm hauv vivo phage zaub technology. CooP tshwj xeeb khi rau mammary{12}} tau txais kev loj hlob inhibitor / fatty acid binding protein 3 (MDGI / FABP3), uas tau nthuav tawm heev hauv glioblastoma (GBM) hlwb thiab lawv cov vasculature txuam. Glioblastoma yog cov qog hlwb uas tshwm sim ntau tshaj plaws thiab mob hnyav tshaj plaws rau cov neeg laus, thiab vim muaj cov ntshav - hlwb teeb meem (BBB) thiab cov qog nqaij hlav loj heev, cov kev kho mob ib txwm muaj tsawg. Raws li glioblastoma-homing peptide, CooP tshwj xeeb yog tsom rau cov hlwb glioblastoma thiab qog vasculature, xa cov tshuaj siv tshuaj khomob, cov tshuaj nanoparticles, lossis cov tshuaj pleev xim rau cov qog nqaij hlav, ua rau cov qog nqaij hlav hauv zos thiab txo cov kev mob tshwm sim ntawm cov kab mob lom. N-terminal cysteine residue ntawm CooP tuaj yeem siv rau covalent conjugation nrog cov khoom thauj khoom. Cov kev tshawb fawb tau pom tias CooP-hloov nanoparticles nthuav tawm cov qog nqaij hlav tseem ceeb thiab cov teebmeem kev kho mob hauv cov qauv glioblastoma, ua rau nws yog ib qho tseem ceeb cov cuab yeej peptide rau lub hlwb qog-cov tshuaj xa mus thiab kev tshawb fawb molecular. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Cov | CooP nyuv- phiaj peptide; plab hnyuv qog aiming peptide | Cov qog nqaij hlav peptide, qog nqaij hlav qog noj ntshav tshwj xeeb khi, cov tshuaj xa mus rau lub plab zom mov | Cov tshuaj decapeptide tshwj xeeb tau tshuaj xyuas rau kev mob qog noj ntshav; khi nrog siab affinity rau lub hom phiaj receptors overexpressed nyob rau saum npoo ntawm cov qog nqaij hlav qog noj ntshav, kho kom haum xeeb cov tshuaj enrichment. | C₄₇H₇₀N₁₄O₁₄ | 1030.52 | ~1031.3 | Acetate | 10 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-COP001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble hauv dej, dilute acetic acid thiab PBS. Optimal receptor binding kev ua haujlwm ntawm lub cev pH; conformational hloov thiab khi kev ua si poob nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-COP001 | CooP nyuv- phiaj peptide tshwj xeeb khi cov kab mob qog noj ntshav rau cov tshuaj siv tshuaj ntxiv | CooP peptide yog kab mob qog noj ntshav - tshwj xeeb lub hom phiaj peptide tshuaj xyuas los ntawm phage zaub. Nws khi nrog siab affinity rau cov yam ntxwv receptors overexpressed ntawm cov qog nqaij hlav qog noj ntshav, kho cov phiaj xwm kev sib txuas ntawm cov kws khomob, cov tshuaj ntsuam xyuas thiab cov nanoparticles hauv cov ntaub so ntswg qog noj ntshav, txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim. | Kev kho mob qog noj ntshav, kev kuaj mob qog noj ntshav, kev txhim kho tshuaj tsom, kev tshawb fawb kab mob hauv plab, kuaj qog molecular | Colon cancer nto lub hom phiaj receptor; receptor-mediated endocytosis; qog- phiaj xwm ntxiv |
Cim npe nrov: CAS 1192864-27-9 coop, Tuam Tshoj cas 1192864-27-9 coop manufacturers, lwm tus neeg, Hoobkas
