Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm pvec (cadherin-5, vascular endothelial cadherin- tau txais peptide) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo pvec (cadherin-5, vascular endothelial cadherin-derived peptide) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | pVEC (Cadherin-5, CAS: 383430-30-6) yog 18-amino acid cell-peptide nkag tau los ntawm residues 615-632 ntawm murine vascular endothelial caherin (VEcad{2}) Cadherin-5), nrog rau qib LLIILRRRRIRKQAHAHSK. N-terminal thaj tsam ntawm pVEC (LLIIL) yog nplua nuj nyob rau hauv hydrophobic residues, thaum lub sij hawm C-terminal cheeb tsam (RRRIRKQAHAHSK) yog nplua nuj nyob rau hauv zoo them nqi arginine thiab lysine residues, nthuav tawm cov qauv amphipathic. Ib qho tseem ceeb ntawm pVEC yog tias nws cov cellular uptake yog feem ntau ua tiav los ntawm txoj kev tsis yog endocytic (direct transmembrane translocation), thiab tus nqi ntawm translocation tsis cuam tshuam los ntawm kub txo los yog endocytosis inhibitors, nws txawv ntawm ntau CPPs uas nkag mus rau hauv hlwb los ntawm endocytic txoj kev. pVEC ua tau zoo nkag mus rau hauv cov cell membranes ntawm ntau hom tsiaj (nrog rau cov hlwb cog) ntawm cov micromolar concentrations tsawg yam tsis muaj kev cuam tshuam rau cov cell membrane ncaj ncees, nrog tsawg cytotoxicity. pVEC tuaj yeem xa cov khoom thauj macromolecular (piv txwv li, cov proteins, peptide nucleic acids, nucleic acids) rau hauv cov hlwb los ntawm covalent conjugation, thiab yog dav siv rau kev xa tshuaj intracellular, hloov cov protein, thiab kev tshawb fawb noob caj noob ces. Tsis tas li ntawd, fusion conjugates ntawm pVEC nrog qog-homing peptides (piv txwv li, PEGA) tuaj yeem ua tiav cov phiaj xwm xa mus rau cov ntaub so ntswg cancer ntawm lub mis, nrog rau daim ntawv thov muaj peev xwm hauv kev tshawb fawb qog-targeted. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| PVEC (Cadherin-5) | pVEC peptide muab tau los ntawm vascular endothelial cadherin; ntshav- hlwb barrier penetrating peptide | Cell-kev nkag mus peptide, vascular endothelial targeting, ntshav-brain barrier delivery, vascular xa tshuaj | Cationic amphiphilic octadecapeptide muab tau los ntawm vascular endothelial cadherin (VE-cadherin); zoo nkag mus rau vascular endothelial cell txheej thiab kho cov tshuaj xa mus thoob plaws cov ntshav -b hlwb barrier | C₉₇H₁₅₇N₂₉O₂₁ | 2180.21 | ~2181.8 | Acetate | 18 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-PVE001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Cationic amphiphilic peptide yog dawb do soluble hauv dej, dilute acetic acid thiab PBS. Zoo stability nyob rau hauv acidic rau nruab nrab tej yam kev mob; hydrophobic domain aggregation thiab nkag mus ua si poob nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PVE001 | pVEC endothelial penetrating peptide muab tau los ntawm cadherin rau cov ntshav ua tau zoo- lub paj hlwb barrier xa | pVEC peptide yog cell -peptide nkag tau los ntawm extracellular domain ntawm VE-cadherin. Nrog rau ob qho tib si cationic thiab amphiphilic zog, nws zoo nkag mus rau vascular endothelial khaubncaws sab nraud povtseg thiab mediates xa cov tshuaj, nucleic acids thiab proteins thoob plaws cov ntshav- hlwb barrier rau hauv lub hlwb. Nrog kev xa khoom siab thiab kev cuam tshuam tsawg kawg ntawm endothelial barrier kev ncaj ncees. | Ntshav-b hlwb barrier xa, CNS tshuaj txhim kho, kev tshawb fawb txog noob caj noob ces, vascular endothelial biology, hlwb- hom tshuaj xa | VE-cadherin; endothelial nruj junctions; trans-barrier xa |
Cim npe nrov: pvec (cadherin{1}}5, vascular endothelial cadherin- muab tau peptide), Tuam Tshoj pvec (cadherin-5, vascular endothelial cadherin-derived peptide) manufacturers, lwm tus neeg, Hoobkas
