Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1369966-01-7 cady hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1369966-01-7 cady los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | CADY (CAS: 1369966-01-7) yog 20-amino acid theem nrab amphipathic cell-peptide nkag tau los ntawm ppTG1 carrier peptide, uas nws tus kheej yog muab los ntawm fusion peptide JTS1. Nws cov kab ke GLWRALWRLLRSLWRLLWRA yog nplua nuj nyob rau hauv tryptophan (Trp, 4 residues) thiab arginine (Arg, 4 residues), txais yuav ib tug -helical conformation nyob rau hauv daim nyias nyias ib puag ncig nrog ib txwm ob qho tib si amphipathicity: arginine residues muab faib rau lwm lub ntsej muag ntawm tus nqi, thaum lub sij hawm helical conformation. residues ntawm lwm lub ntsej muag muab daim nyias nyias anchoring thiab insertion muaj peev xwm. CADY tshwj xeeb yog tsim los tsim cov khoom ruaj khov uas tsis yog-covalent complexes nrog nucleic acids (tshwj xeeb yog siRNA) los ntawm electrostatic thiab hydrophobic kev sib cuam tshuam, tiv thaiv siRNA los ntawm nuclease degradation thiab zoo kho cellular uptake thiab endosomal khiav. Piv rau cov tsoos cationic polymer thiab liposome transfection reagents, CADY nthuav tawm qis cytotoxicity thiab siab dua siRNA kev xa khoom zoo yam tsis ua rau lub cev tiv thaiv kab mob. CADY tau ua tiav zoo rau kev xa tawm siRNA thiab cov gene silencing nyob rau hauv ntau cov kab ntawm tes, suav nrog cov thawj cov hlwb thiab cov hlwb nyuaj, ua rau nws yog ib qho cuab yeej tseem ceeb rau RNA cuam tshuam txoj kev kho thiab kev tshawb fawb gene. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| CADY | CADY nucleic acid xa peptide; siRNA siab -efficiency transfection peptide | Nucleic acid xa peptide, zoo siRNA transfection, gene silencing tshawb fawb, cell nkag | Amphiphilic cationic 20-mer peptide nrog alternating hydrophobic aromatic residues thiab cationic arginines; nws tus kheej sib sau ua ke nrog siRNA rau hauv cov nanocomplexes ruaj khov ntawm electrostatic thiab hydrophobic kev sib cuam tshuam rau cov cellular uptake thiab gene silencing | C₁₀₆H₁₆₉N₂₉O₂₁ | 2256.29 | ~2257.8 | Acetate | 20 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-CAD001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Amphiphilic peptide muaj solubility zoo nyob rau hauv acidic tej yam kev mob; yooj yim rau tus kheej- sib dhos thiab sib sau ua ke ntawm nruab nrab pH. Tsis txhob premixing nrog nucleic acids; npaj complexes tam sim ntawd ua ntej siv. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CAD001 | CADY amphiphilic peptide tus kheej- sib sau ua ke nrog siRNA kom muaj txiaj ntsig gene silencing | CADY yog ib qho amphiphilic cationic peptide tsim los rau nucleic acid xa. Alternating hydrophobic aromatic residues thiab cationic arginines nyob rau hauv ib theem ua kom tus kheej spontaneous tus kheej -sembly nrog siRNA mus rau hauv ruaj khov nanocomplexes ntawm electrostatic thiab hydrophobic kev sib cuam tshuam, tiv thaiv siRNA los ntawm degradation thiab mediating npaum cellular uptake thiab intracellular tso tawm rau potent gene silen. Nrog rau siab transfection efficiency thiab qis cytotoxicity, nws yog ib qho cuab yeej classic rau siRNA xa thiab gene silencing tshawb fawb. | siRNA kev xa khoom & gene silencing, nucleic acid tshuaj txhim kho, CPP thev naus laus zis, kev tshawb fawb txog noob caj noob ces, tus kheej - sib dhos nanocarriers | siRNA electrostatic complexation; tus kheej- sib dhos nanoparticles; endosomal txoj kev khiav tawm |
Cim npe nrov: CAS 1369966-01-7 cady, Tuam Tshoj cas 1369966-01-7 cady manufacturers, lwm tus, Hoobkas
