Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm tat-nts peptide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo tat-nts peptide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Tat-NTS peptide yog 21-amino acid fusion peptide tsim los ntawm ob lub qauv ua haujlwm: (1) N-terminal TAT cell- nkag mus rau peptide sib lawv liag (YGRKKRRQRRR, sib thooj rau cov khoom seem 45{7} ntawm HIV{14} arginine thiab lysine, muab cov cell membrane nkag tau zoo rau kev sib haum xeeb nkag ntawm tag nrho fusion peptide; (2) the C-terminal NTS (nuclear translocation sequence, SFPHLRRVF), derived from the nuclear translocation signal peptide segment of annexin A1 (ANXA1). Tom qab nkag mus rau hauv hlwb los ntawm TAT ib ntus, NTS ib ntus tshwj xeeb khi thiab inhibits nuclear translocation ntawm annexin A1. Annexin A1 yog calcium -nyob ntawm phospholipid-binding protein uas hloov los ntawm cytoplasm mus rau lub nucleus thaum lub sij hawm cerebral ischemia-reperfusion raug mob, koom nrog hauv neuronal apoptotic signaling pathways. Inhibiting annexin A1 nuclear translocation txo qis neuronal apoptosis tom qab ischemic hlwb raug mob, exerting neuroprotective teebmeem. Cov kev tshawb fawb tau pom tias Tat-NTS peptide ua tau zoo txo cerebral infarct ntim thiab txhim kho neurological deficits nyob rau hauv ib tug nas nruab nrab cerebral artery occlusion (MCAO) qauv, ua rau nws ib tug promising neeg sib tw peptide rau neuroprotective kev kho mob ntawm ischemic stroke. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Tat-NTS peptide | Tat nucleolar tsom peptide; Tat-NTS fusion xa peptide | Cell nkag mus + nucleolar targeting, noob/protein nuclear xa, subcellular localization kawm | Tat cell-ntxuav ntu (residues 49–57) conjugated nrog nucleolar targeting signal (NTS); Tat mediates zoo transmembrane nkag, NTS mediates tom ntej nucleolar targeted xa | C₉₈H₁₅₈N₃₈O₂₃ | 2255.22 | ~2256.7 | Acetate | 18 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-TNT001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble hauv dej, dilute acetic acid thiab PBS. Zoo stability nyob rau hauv acidic rau nruab nrab tej yam kev mob; conformational hloov ntawm nuclear localization teeb liab thiab lub hom phiaj kev ua si txo nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TNT001 | Tat-NTS fusion peptide enables cell penetration + nucleolar targeting kom meej subcellular xa | Tat-NTS peptide yog cov cuab yeej ua haujlwm subcellular xa khoom. Lub N-terminal Tat ntu (classic cell-xov xwm sib txuas) kho kom zoo dua transmembrane nkag mus rau hauv cov hlwb, thiab C-terminal nucleolar targeting signal (NTS) mediates tom qab thauj thiab txhawb nqa hauv thaj av nucleolar. Nws xa cov nucleic acids, cov proteins thiab cov tshuaj molecule me me rau cov nucleolus, ua ib qho cuab yeej tseem ceeb rau cov qauv nucleolar / kev tshawb fawb txog kev ua haujlwm thiab nuclear- phiaj xwm kev tsim tshuaj. | Nuclear -kev tshawb fawb tshuaj, kev tshawb fawb subcellular localization, gene qhia kev tswj, nucleolar function research, CPP technology | Phospholipid bilayer; nucleolar localization teeb liab txoj kev; Tat-kev hloov pauv hloov pauv hloov pauv |
Cim npe nrov: tat-nts peptide, Tuam Tshoj tat-nts peptide manufacturers, lwm tus neeg, Hoobkas
