Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas 2293160-09-3 ph-low insertion peptide (phlip) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 2293160-09-3 ph-tsawg insertion peptide (phlip) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | pH-Low Insertion Peptide (pHLIP, CAS: 2293160-09-}3) yog 36-amino acid pH-tej daim nyias nyias-Inserting peptide muab tau los ntawm kev tsim kho kom zoo ntawm cov kab mob C{12. pHLIP nthuav tawm cov pH tshwj xeeb- tus cwj pwm nyob ntawm: ntawm nruab nrab pH (physiological pH 7.4), pHLIP tshwm sim raws li cov dej sib tov sib xyaw ua ke hauv cov kua dej, tsuas yog tsis muaj zog nrog cov cell membrane nto; Thaum cov pH ib puag ncig txo qis rau acidic tej yam kev mob (pH <6.0, xws li nyob rau hauv cov qog microenvironments, cov ntaub so ntswg ischemic, thiab inflammatory sites), protonation ntawm aspartic acid thiab glutamic acid residues ua rau ib tug conformational kev hloov, folding rau hauv ib tug ruaj khov transmembrane -helix uas ntxig rau hauv cell membrane. Qhov pH-triggered membrane insertion mechanism ua rau pHLIP tshwj xeeb rau cov qog nqaij hlav acidic (xws li cov qog nqaij hlav ntxov thiab metastatic), xa cov tshuaj tiv thaiv kab mob sib txuas (xws li, fluorescent dyes, radionuclides) lossis tshuaj kho rau cov qog hlwb. N-terminal cysteine residue ntawm pHLIP tuaj yeem siv rau cov khoom sib txuas nrog cov khoom thauj khoom. pHLIP tau ua tiav hauv cov qog kho qhov muag, PET imaging, photodynamic therapy, thiab chemotherapeutic tshuaj xa, ua rau nws yog ib qho tseem ceeb cov cuab yeej peptide rau qog acidic microenvironment tsom kev tshawb fawb. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| pH-Low Insertion Peptide | pH qis qis peptide; pHLIP acidic membrane insertion peptide | pH- teb lub hom phiaj peptide, qog acidic microenvironment, xa tshuaj intracellular, endosomal khiav | pH- teb amphiphilic -helical peptide; soluble thiab dispersed nyob rau hauv nruab nrab tej yam kev mob, undergoes hydrophobic conformational hloov ntawm pH <6.0 mus rau ntxig rau hauv lipid bilayer ntawm cell membranes | C₁₁₆H₁₉₀N₃₂O₃₄ | 2607.43 | ~2609.1 | Acetate | 23 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-PHL001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid, nruab nrab buffers thiab DMSO. pH- teb peptide; soluble thiab ruaj khov ntawm nruab nrab pH, undergoes hydrophobic conformational hloov thiab membrane insertion / aggregation ntawm pH 6.0. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PHL001 | pHIP pH- teb qhov ntxig peptide lub hom phiaj acidic qog microenvironment rau intracellular xa | pH-Low Insertion Peptide (pHLIP) yog ib qho pH classic- teb cov membrane insertion peptide. Nws tshwm sim li soluble random coil ntawm nruab nrab physiological pH. Thaum nkag mus rau hauv acidic qog microenvironment (pH 5.5-6.5) los yog endosomes, acidification ua rau folding rau hauv hydrophobic -helix uas ntxig rau hauv lub lipid bilayer, xa cov tshuaj conjugated, nucleic acids thiab co toxins mus rau hauv lub cytoplasm, ua kom lub hom phiaj xa mus rau cov qog nqaij hlav. | Kev kho mob qog nqaij hlav, pH- teb cov tshuaj xa, kev tshawb fawb txog noob caj noob ces, endosomal khiav tawm tshuab, qog microenvironment kev tshawb fawb | Phospholipid bilayer; pH-kev hloov pauv hloov pauv; acidic membrane insertion txoj kev |
Cim npe nrov: cas 2293160-09-3 ph-low insertion peptide (phlip), Tuam Tshoj cas 2293160-09-3 ph-low insertion peptide (phlip) manufacturers, lwm tus neeg, Hoobkas
