Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 454487-07-1 lyp-1 (cov qog lymphatic homing peptide) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale tej yam zoo li cas 454487-07-1 lyp-1 (mob lymphatic homing peptide) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | LyP-1 (CAS: 454487-07-1) yog 9-amino-acid disulfide-bridged cyclic peptide nrog cov kab ke Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys (CGNKRTRGC), nyob rau hauv uas ib tug disulfide daim ntawv cog lus yog tsim los ntawm Cys1 thiab Cys9, tuav lub voj voog. LyP-1 yog thawj zaug cais los ntawm Laakkonen li al. hauv xyoo 2002 los ntawm hauv vivo phage tso saib thev naus laus zis siv MDA-MB-435 tib neeg mob qog noj ntshav xenograft qauv, thiab yog cov qog nqaij hlav qog nqaij hlav qog nqaij hlav homing peptide. Lub hom phiaj ntawm LyP-1 yog p32 protein (tseem hu ua gC1qR, C1q binding protein, HABP1), cov protein ntau ua haujlwm feem ntau hauv cheeb tsam hauv mitochondrial matrix, tab sis kuj tau nthuav tawm rau saum npoo ntawm cov qog hlwb thiab cov qog- txuam nrog cov qog nqaij hlav hauv lub cev, cov kab mob hauv lub cev, thiab cov qog nqaij hlav. metastasis. Cov yam ntxwv tseem ceeb ntawm LyP-1: (1) qog lymphatic targeting - LyP-1 tuaj yeem tshwj xeeb hauv tsev rau cov kab mob lymphatic ntawm ntau hom qog nqaij hlav (xws li MDA-MB-435 mob qog noj ntshav mis, C8161 melanoma), thiab sib sau nyob rau hauv cov kab mob qog nqaij hlav qog nqaij hlav; (2) cell- nkag mus rau hauv kev ua si - LyP-1 tsis tuaj yeem khi rau ntawm lub xov tooj ntawm tes p32 receptors, tab sis kuj nkag mus rau hauv cov cell membrane rau hauv lub cell thiab localize mus rau lub nucleus, nthuav tawm cov yam ntxwv ntawm cov cell-peptide; (3) cyclic conformational stability - lub cyclic conformation tswj los ntawm disulfide daim ntawv cog lus txhim kho lub peptide tus tsis kam mus rau protease degradation thiab tswj qhov zoo conformation rau p32 receptor khi; (4) p32 receptor tshwj xeeb - kev khi ntawm LyP-1 rau p32 protein muaj kev sib raug zoo thiab tshwj xeeb, thiab tuaj yeem siv rau p32 receptor kev tshawb fawb thiab lub hom phiaj. Cov ntawv thov ntawm LyP-1 muaj xws li: (1) qog lymphatic imaging - tom qab daim ntawv lo nrog fluorescent dyes (xws li FITC, Cy5) los yog radionuclides, siv rau kev pom cov qog lymphatics thiab kev ntsuam xyuas ntawm lymphatic metastasis; (2) qog-tsom tshuaj xa - conjugating chemotherapeutic tshuaj, nanoparticles, siRNA, los yog gene therapy reagents nrog LyP-1 rau lub hom phiaj xa mus rau qog lymphatics thiab qog hlwb, inhibiting qog loj hlob thiab lymphatic metastasis; (3) p32 receptor biology tshawb fawb - ua ib lub cuab yeej peptide los kawm txog lub luag haujlwm ntawm p32 protein nyob rau hauv cov qog metabolism, proliferation, thiab metastasis; (4) qog metastasis mechanism kev tshawb fawb - tshawb xyuas lub luag haujlwm ntawm lymphatics hauv qog metastasis thiab cov txheej txheem molecular ntawm LyP-1 tsom rau qog lymphatics; (5) Kev soj ntsuam qog nqaij hlav - qog lymphatic ntom ntom thiab LyP-1 lub hom phiaj yog cuam tshuam nrog qog nqaij hlav metastasis. Daim ntawv TFA ntsev ntawm LyP-1 muaj cov qauv molecular C₃₈H₆₆F₃N₁₇O₁₄S₂ thiab molecular hnyav ntawm 1106.16 Da. LyP-1 yog cov cuab yeej tseem ceeb peptide rau kev kawm cov qog lymphatic biology thiab tsim cov qog nqaij hlav qog nqaij hlav thiab kho cov tswv yim kho mob. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| LyP-1 | LyP-1 lymphoma- phiaj peptide; p32 receptor-targeted cyclic peptide | Lymphoma targeting, qog- targeted delivery, qog imaging, receptor-binding peptide | Lymphoma- tsom rau nonapeptide tshuaj xyuas los ntawm phage zaub, cyclized ntawm intramolecular disulfide daim ntawv cog lus ntawm cysteine; tshwj xeeb khi p32 receptor overexpressed ntawm cov qog ntshav qog ntshav los kho cov tshuaj tiv thaiv kab mob | C₃₇H₆₀N₁₄O₉S₂ | 880.4 | ~881.0 | Acetate | 9 (cyclic nonapeptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-LYP01 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble hauv dej, dilute acetic acid thiab PBS. Intramolecular disulfide daim ntawv cog lus yog rhiab heev rau muaj zog txo cov neeg ua haujlwm thiab siab -concentration thiol compounds; Nws yooj yim rau disulfide cleavage thiab cyclic conformation cuam tshuam. Tsis txhob ua ke nrog cov tshuaj txo qis. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-LYP01 | LyP-1 lymphoma-targeting cyclic peptide khi p32 receptor rau lub hom phiaj xa khoom | LyP-1 yog lymphoma- tsom rau cyclic peptide soj ntsuam los ntawm phage zaub. Nws khi nrog siab affinity rau p32 (gC1qR) receptor overexpressed ntawm lymphoma hlwb, thiab mediates intracellular xa ntawm conjugated chemotherapeutics, fluorescent probes thiab nanoparticles ntawm receptor-mediated endocytosis, txhim kho qog tshuaj concentration thiab txo cov kev mob tshwm sim. | Lymphoma targeted therapy, qog targeted imaging, targeted drug development, hematologic oncology research, molecular imaging diagnosis | p32/gC1qR receptor; receptor-mediated endocytosis; qog nqaij hlav tsom enrichment |
Cim npe nrov: CAS 454487-07-1 lyp-1 (cov qog lymphatic homing peptide), Tuam Tshoj cas 454487-07-1 lyp-1 (cov qog lymphatic homing peptide) manufacturers, lwm tus neeg, Hoobkas
