Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 187735-94-0: bio-1211 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 187735-94-0: bio-1211 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 187735-94-0: BIO-1211 Nr |
| Kev piav qhia | BIO-1211 yog ib qho kev xaiv peptide antagonist ntawm integrin 4 1 (VLA-4). Nws sib tw khi rau ligand{10}} khi hnab tshos ntawm integrin 4 1, thaiv cov adhesion thiab migration ntawm lymphocytes thiab monocytes rau vascular endothelial hlwb thiab extracellular matrix, yog li txo lub cev tiv thaiv kab mob infiltration thiab inflammatory teb ntawm inflammatory sites. Nws muaj kev xaiv ntau dua rau 4 1 integrin dua li lwm yam integrin subtypes, thiab qhia meej txog kev tiv thaiv kab mob hauv cov kab mob autoimmune thiab inflammatory kab mob xws li ntau yam sclerosis, mob hawb pob thiab mob plab hnyuv. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb integrin thiab kev txhim kho tshuaj tiv thaiv peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb peptide molecular mis | C₄₀H₆₂N₈O₉ |
| Dawb peptide molecular hnyav (Da) | 790.97, siab dua rau daim ntawv ntsev |
| Hom qauv | Linear heptapeptide, optimized integrin-binding sequence, dawb peptide / acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| BIB-1211 | Integrin 4 1 antagonist peptide | Integrin 4 1 antagonist, inhibits immune cell adhesion, tiv thaiv - mob, kev tshawb fawb kab mob autoimmune | Linear heptapeptide optimized raws li LDV core sequence ntawm fibronectin CS-1 domain, xaiv khi rau ligand hnab tshos ntawm integrin 4 1 thiab thaiv cell-matrix adhesion thiab tsiv teb tsaws | Dawb peptide: C₄₀H₆₂N₈O₉ | 790.47 | 790.97 | Dawb peptide / acetate | 7 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-BIO001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau luv - lub sij hawm shipping ntawm ambient kub. | Nyob ruaj khov rau 14 hnub ntawm 4 degree. Dawb soluble hauv dej, PBS tsis thiab dilute acetic acid. Aqueous tov yog raug rau proteolytic degradation; aliquot sterilely thiab khov tom qab reconstitution. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-BIO001 | Kev xaiv siab heev 4 1 integrin antagonist peptide inhibits lub cev tiv thaiv kab mob ntawm tes thiab ua rau muaj kev tiv thaiv - cov teebmeem inflammatory | BIO-1211 yog ib qho kev xaiv peptide antagonist ntawm integrin 4 1 (VLA-4). Nws sib tw khi rau ligand{10}} khi hnab tshos ntawm integrin 4 1, thaiv cov adhesion thiab transendothelial migration ntawm lymphocytes thiab monocytes rau vascular endothelial VCAM-1 thiab extracellular matrix fibronectin, yog li txo cov kab mob hauv lub cev hauv cov ntaub so ntswg. Nws muaj kev xaiv ntau dua rau 4 1 integrin dua li lwm cov integrin subtypes uas muaj cov txiaj ntsig tsis zoo, thiab qhia meej txog kev tiv thaiv kab mob hauv cov kab mob autoimmune thiab inflammatory kab mob xws li ntau yam sclerosis, mob hawb pob thiab mob plab hnyuv. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb integrin thiab kev txhim kho tshuaj tiv thaiv peptide. | Kev tshawb fawb ntau yam sclerosis, kev tshawb fawb txog kev mob ntsws asthma, kev tshawb fawb txog kab mob plab hnyuv, kev tiv thaiv kab mob hauv lub cev thiab kev tshawb nrhiav kev tsiv teb tsaws, kev ua haujlwm integrin thiab kev txhim kho tshuaj. | Integrin 4 1 (VLA-4); Cell adhesion thiab migration txoj kev |
Cim npe nrov: cas:187735-94-0: bio-1211, Tuam Tshoj cas:187735-94-0: bio-1211 manufacturers, lwm tus, Hoobkas
