Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 2014384-91-7 nangibotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 2014384-91-7 nangibotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 2014384-91-7: Nangibotide |
| Kev piav qhia | Nangibotide (tseem hu ua LR12) yog ib qho tshwj xeeb antagonist peptide lub hom phiaj ua rau cov neeg txais kev pom ntawm myeloid hlwb 1 (TREM-1). Nws sib tw khi rau TREM-1 receptors, blocks endogenous ligand-mediated receptor activation thiab downstream inflammatory signaling pathways, inhibits pro-inflammatory cytokine cua daj cua dub thiab ntau heev myeloid cell activation, thaum tsis cuam tshuam rau lub cev antibacterial tiv thaiv ntawm lub cev. Nws tuaj yeem txo qis kev raug mob ntau dhau thiab txhim kho txoj sia nyob hauv cov qauv ntawm sepsis, septic shock thiab mob hnyav. Nws yog cov cuab yeej txiav peptide rau kev kawm txog kev mob hnyav thiab kev tiv thaiv kab mob. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular hnyav (Da) | ~ 1400 (raws li qhov tseeb hluavtaws batch) |
| Hom qauv | Linear dodecapeptide, haiv neeg amino acid sequence |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Hloov kho hom | Ntev (aa) |
| Nangibotide | Nangibotide; LR 12 | TREM-1 antagonism, Cytokine cua daj cua dub inhibition, Sepsis tshawb fawb, Immunomodulation, mob hnyav los tiv thaiv, Peptide tshuaj | TREM-1 ligand homologous dodecapeptide nrog receptor binding core sequence | Loj linear peptide, raws li qhov tseeb batch MS | - | ~ 1400 (theoretical) | Native tsis hloov | 12 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-NAN001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; tsis txhob rov qab khov-thaw cycles thiab kis kab mob | ruaj khov rau 2 lub lis piam ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 72h ntawm 4℃nyob rau hauv tsis muaj menyuam; Nws yooj yim rau degradation thiab inactivation los ntawm serum proteases ntawm chav tsev kub ** zoo solubility dej, dawb soluble nyob rau hauv nruab nrab physiological tsis **. Linear luv peptide yooj yim degraded los ntawm proteases | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NAN001 | TREM-1 receptor tshwj xeeb antagonist peptide uas thaiv cov kab mob inflammatory ntau dhau thiab txo qhov mob hnyav xws li mob plab. | Nangibotide muaj kev sib tw TREM-1 receptors ntawm myeloid cell nto los ntawm kev ua raws li kev sib txuas ntawm cov ligands endogenous, blocks ligand-induced receptor dimerization thiab ua kom qis qis SYK thiab NF-κB inflammatory signaling pathways, inhibits qhov loj heev - TNF- , IL-1 thiab IL-6, thiab alleviates cytokine cua daj cua dub thiab cov ntaub so ntswg puas. Sib txawv ntawm cov tshuaj tiv thaiv kab mob dav dav, nws tsuas yog tsom rau TREM-1-kho cov kab mob ntau dhau, tsis cuam tshuam cov kab mob-tshuaj tiv thaiv kab mob hauv lub cev, nrog kev pheej hmoo kis tus kab mob tsawg. Nws yog cov cuab yeej tshiab tsom rau kev kawm txog kev kis mob hnyav, mob tsis muaj menyuam thiab lwm yam kab mob. | Sepsis thiab septic shock, Kev tshawb fawb mob hnyav, Cytokine cua daj cua dub mechanism, Myeloid cell tiv thaiv, mob hauv nruab nrog cev, Anti-inflammatory peptide kev loj hlob | Triggering Receptor Qhia rau Myeloid cells 1 (TREM-1); SYK/NF-κB inflammatory signaling txoj kev; Cytokine cua daj cua dub inhibitory txoj kev |
Cim npe nrov: CAS 2014384-91-7 nangibotide, Tuam Tshoj cas 2014384-91-7 nangibotide manufacturers, lwm tus neeg, Hoobkas
