Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1234319-68-6 tak-448 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo cas 1234319-68-6 tak-448 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1234319-68-6: TS-448 |
| Kev piav qhia | TAK-448 yog ib lub cim tshiab uas muaj zog heev kisspeptin receptor agonist peptide. Nws khi thiab qhib G protein-coupled KISS1R receptors nrog siab affinity, pib nkoos gonadotropin-tso cov tshuaj hormone secretion, thaum lub sij hawm tuav tswj induces receptor desensitization, downregulates lub hypothalamic-pituitary-gonadal axis muaj nuj nqi, thiab tseem inhibits lub synthesis thiab secretion ntawm txiv neej pw. Nrog muaj zog tiv thaiv-proteolytic muaj peev xwm thiab ntev hauv vivo ib nrab-lub neej tom qab kev hloov kho cov qauv, nws yog cov cuab yeej tshiab peptide rau kev mob qog noj ntshav prostate, cov kab mob sib deev-nyob ntawm cov kab mob thiab kev tshawb fawb txog kev xeeb tub. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular hnyav (Da) | ~ 1300 (raws li qhov tseeb hluavtaws batch) |
| Hom qauv | Hloov kho decapeptide nrog ntau qhov chaw unnatural amino acid hloov pauv |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hloov kho hom | Ntev (aa) |
| TSI-448 | TAK-448; Kisspeptin agonist | KISS1R agonism, Kev sib deev hormone secretion inhibition, Prostate cancer tshawb fawb, Reproductive endocrinology, Ntev - ua haujlwm ruaj khov, Hloov peptide | Kisspeptin-10 homologous caj qaum nrog ntau qhov chaw hloov kho rau kev ua kom zoo dua receptor affinity thiab metabolic stability | Loj hloov peptide, raug rau cov batch MS | - | ~ 1300 (theoretical) | Unnatural amino acid hloov pauv + davhlau ya nyob twg hloov kho | 10 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-TAK001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 7 hnub ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Dej solubility nruab nrab, soluble nyob rau hauv dilute acetic acid los yog weakly acidic tsis **. Anti-enzymatic muaj peev xwm ho zoo dua li ib txwm kisspeptin tom qab hloov kho | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TAK001 | Ntev - ua yeeb yam KISS1R agonist peptide uas induces receptor desensitization nrog kev tswj xyuas ruaj khov thiab muaj zog inhibits gonadal axis thiab kev sib deev hormone secretion | TAK-448 qhib Gq/PLC/IP3/Ca²⁺ taw qhia txoj hauv kev los ntawm kev khi tshwj xeeb khi KISS1R receptors rau ntawm qhov chaw ntawm hypothalamic GnRH neurons. Pulsed thawj thawj coj txhawb nqa GnRH thiab gonadotropin secretion; Kev tswj hwm kev ruaj ntseg ua rau receptor internalization thiab desensitization, reversibly inhibits hypothalamic -pituitary-gonadal axis muaj nuj nqi, txo qis kev nce qib testosterone thiab estrogen, thiab ua rau cov tshuaj pharmacological castration nyhuv. Piv nrog rau ib txwm kisspeptin, nws lub peev xwm los tiv thaiv peptidase degradation tau zoo heev tom qab ntau- hloov kho qhov chaw, nrog rau lub sijhawm ntev heev hauv vivo ib nrab- lub neej thiab muaj txiaj ntsig zoo dua. Nws yog ib qho cuab yeej siv tau zoo rau kev sib deev hormone-dependent kab mob thiab kev tshawb fawb txog kev xeeb tub endocrine. | Kev tshawb fawb txog mob qog noj ntshav prostate, Kev sib deev hormone- cov kab mob nyob hauv, Kev tsim kho cov kab mob endocrine, kev txhim kho pubertal, kev tshawb fawb tshuaj castration, Peptide tshuaj txhim kho | Kisspeptin Receptor (KISS1R/GPR54); GnRH/gonadotropin secretion txoj kev; Hypothalamic-pituitary-gonadal axis tswj txoj hauv kev |
Cim npe nrov: CAS 1234319-68-6 tak-448, Tuam Tshoj cas 1234319-68-6 tak-448 manufacturers, lwm tus, Hoobkas
