Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 107658-43-5 gala hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 107658-43-5 gala los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | GALA (CAS: 107658-43-5) yog pH classic- teb amphipathic -helical membrane fusion peptide nrog cov kab ke WEAALAEALAEALAEHLAEALAEALEALAA (30 amino acids). GALA tau tsim los ntawm N-terminal fusion peptide ntawm tus kab mob khaub thuas hemagglutinin, thiab nws lub npe muab los ntawm "Glutamic acid-Alanine-Leucine-Alanine" (EALA) rov qab motif. GALA nthuav tawm ib qho tshwj xeeb pH- teb cov cuab yeej hloov pauv hloov pauv: (1) ntawm nruab nrab pH (pH 7.4), sab saw carboxyl pawg ntawm glutamic acid (Glu, E, 7 tag nrho) residues yog deprotonated thiab tsis zoo them; electrostatic repulsion ntawm cov nqi tsis zoo nyob rau hauv peptide saw ua rau GALA muaj nyob rau hauv ib tug random coil conformation, nrog zoo solubility ntawm dej thiab tsis muaj daim nyias nyias kev ua si; (2) ntawm acidic pH (pH 5.0-6.0, sib haum mus rau qhov chaw endosomal/lysosomal), glutamic acid residues ua protonated (pKa ~ 4.3), cov nqi tsis zoo ploj, thiab GALA folds rau hauv amphipathic -helical qauv qhov twg hydrosphobic residues ntawm lub ntsej muag, thiab hydrophilic residues (Glu, Nws) pawg ntawm lwm yam; Lub ntsej muag hydrophobic tuaj yeem nkag mus rau hauv cov cell membrane lipid bilayer, cuam tshuam cov membrane kev ncaj ncees thiab inducing membrane fusion thiab pore tsim. GALA kuj muaj ib qho histidine (Nws, H) residue uas nws imidazole pawg muaj pKa ntawm ~ 6.0, ua protonated thiab zoo them nyob rau hauv acidic tej yam kev mob, ntxiv txhim kho peptide khi rau tsis zoo them nyiaj endosomal daim nyias nyias. GALA's pH-kev ua haujlwm ntawm cov membrane fusion ua rau nws yog ib qho ntawm feem ntau siv endosomal dim peptides hauv cov noob thiab cov tshuaj xa mus. Nws tuaj yeem txuas nrog cationic polymers, liposomes, nanoparticles, thiab cell - nkag mus rau peptides los pab cov cargo khiav tawm ntawm endosomes mus rau hauv cytoplasm, zam lysosomal degradation. GALA yog dav siv rau: (1) DNA / mRNA / siRNA xa hauv kev kho noob thiab kho noob; (2) intracellular xa cov protein thiab peptide tshuaj; (3) tsim pH- teb nanodrug nqa; (4) biophysical kev tshawb fawb ntawm membrane fusion mechanisms thiab peptide-membrane kev sib cuam tshuam; (5) qauv kev tshawb fawb ntawm cov kab mob nkag mechanisms. GALA yog ib qho cuab yeej classic rau kev kawm pH-xws li membrane-active peptides thiab tsim cov tshuab xa tshuaj ntse. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| GALA | GALA pH- teb membrane fusion peptide; endosomal khiav peptide | pH- teb fusion fusion, endosomal khiav, gene / tshuaj xa tuaj, membrane poration | Amphiphilic -helical peptide nrog rov ua dua Glu-Ala-Leu ib ntus; glutamate protonates nyob rau hauv acidic tej yam kev mob, thiab cov peptide saw folds mus rau hauv ib tug hydrophobic -helix los ntxig rau hauv cell membranes thiab kho endosomal fusion thiab khiav. | C₁₃₀H₂₃₅N₂₇O₄₂ | 2808.71 | ~2810.3 | Acetate | 30 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-GALA01 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid thiab acidic buffers. Classic pH- teb membrane fusion peptide; glutamate protonates nyob rau hauv acidic tej yam kev mob los tsim ib tug ruaj khov -helix nrog zoo solubility. Txhim kho hydrophobicity, aggregation thiab membrane fusion ua haujlwm ntawm nruab nrab pH. Tsis txhob cia ntev -lub sij hawm cia ntawm nruab nrab pH. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-GALA01 | GALA pH- teb membrane fusion peptide ua rau endosomal khiav rau kev txhim kho kev xa khoom | GALA yog ib qho pH classic - teb cov membrane fusion peptide. Nws tshwm sim raws li ib tug soluble random kauj ntawm nruab nrab pH. Thaum nkag mus rau acidic endosomes (pH 5.0–6.0), protonation ntawm glutamic acid residues ua rau folding rau hauv amphiphilic -helix uas ntxig thiab cuam tshuam cov endosomal daim nyias nyias, tiv thaiv co- xa cov nucleic acids, proteins thiab nanomedicines los ntawm kev ua haujlwm zoo heev ntawm kev xa tawm. | Gene transfection & gene therapy, intracellular protein delivery, endosomal escape technology, membrane fusion mechanism tshawb fawb, tshuaj xa cov tshuab | Endosomal phospholipid bilayer; pH-kev hloov pauv hloov pauv; membrane fusion & poration pathway |
Cim npe nrov: CAS 107658-43-5 gala, Tuam Tshoj cas 107658-43-5 gala manufacturers, lwm tus, Hoobkas
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