Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 124584-08-3: nesiritide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 124584-08-3: nesiritide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS : 124584-08-3: Nesiritide |
| Kev piav qhia | Nesiritide yog recombinant tib neeg lub hlwb natriuretic peptide (BNP), endogenous natriuretic peptide secreted los ntawm tib neeg ventricular myocytes. Los ntawm kev khi rau natriuretic peptide receptor A (NPR-A) nyob rau hauv vascular endothelium thiab raum cov ntaub so ntswg, nws activates lub downstream cGMP signaling txoj kev thiab exerts ntau yam kab mob plawv regulator: balanced dilation ntawm cov hlab ntsha thiab cov hlab ntsha, txo lub plawv preload thiab afterload thiab pulmonary artery siab; txhawb nqa lub raum sodium excretion thiab diuresis kom txo cov dej thiab sodium retention; inhibition ntawm kev ua kom ntau dhau ntawm renin -aldosterone system thiab sympathetic paj hlwb. Nws tuaj yeem txhim kho hemodynamics sai sai thiab txo cov tsos mob ntawm lub plawv tsis ua haujlwm hauv cov mob plawv tsis ua hauj lwm thiab cov qauv plawv tsis txaus. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb lub plawv tsis ua haujlwm, tshuaj kho mob plawv thiab natriuretic peptide system ua haujlwm tshawb fawb. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb puag molecular mis | C₁₄₃H₂₄₄N₅₀O₄₂S₄ |
| Dawb puag molecular hnyav (Da) | 3464.02 |
| Hom qauv | 32-mer peptide, ib khub ntawm intramolecular disulfide bonds, dawb peptide / acetate |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Nesiritide | Nesiritide; rhBNP | NPR-A receptor agonist, natriuretic, diuretic & vasodilatory, kev tshawb fawb txog kev kho plawv tsis ua hauj lwm | 32-mer endogenous hlwb natriuretic peptide, ib khub ntawm intramolecular disulfide bonds tsim ib tug cyclic active conformation, activates NPR-A los tswj cov hlab plawv thiab dej-sodium homeostasis | Dawb peptide: C₁₄₃H₂₄₄N₅₀O₄₂S₄ | 3461.78 | 3464.02 | Dawb peptide / acetate | 32 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-NES001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob muaj zog txo cov neeg ua haujlwm thiab rov ua kom khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble nyob rau hauv dilute acetic acid thiab acidic buffers; me ntsis dej solubility. Ntev peptide aqueous tov yog raug rau protease degradation; aliquot sterilely thiab khov rau cia. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NES001 | Recombinant tib neeg lub hlwb natriuretic peptide nrog natriuretic, diuretic thiab vasodilatory teebmeem rau lub plawv tsis ua hauj lwm | Nesiritide yog recombinant tib neeg lub hlwb natriuretic peptide (BNP), endogenous natriuretic peptide secreted los ntawm tib neeg ventricular myocytes. Los ntawm kev khi rau natriuretic peptide receptor A (NPR-A) nyob rau hauv vascular endothelium thiab raum cov ntaub so ntswg, nws activates lub downstream cGMP signaling txoj kev thiab exerts ntau yam kab mob plawv regulator: balanced dilation ntawm cov hlab ntsha thiab cov hlab ntsha, txo cov plawv preload/afterload thiab pulmonary artery siab; txhawb nqa lub raum sodium excretion thiab diuresis kom txo cov dej thiab sodium retention; inhibition ntawm kev ua kom ntau dhau ntawm renin -aldosterone system thiab sympathetic paj hlwb, thiab antagonism ntawm ventricular remodeling. Nws tuaj yeem txhim kho hemodynamics sai sai thiab txo cov tsos mob ntawm lub plawv tsis ua haujlwm hauv cov mob plawv tsis ua hauj lwm thiab cov qauv plawv tsis txaus. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb lub plawv tsis ua haujlwm, tshuaj kho mob plawv thiab natriuretic peptide system ua haujlwm tshawb fawb. | Kev tshawb fawb lub plawv tsis ua hauj lwm mechanism, kev tshawb fawb txog kev mob plawv, kev tshawb fawb natriuretic peptide system ua haujlwm, kev tshawb fawb pulmonary hypertension, ventricular remodeling research | Natriuretic peptide receptor A (NPR-A); cGMP kev taw qhia txoj hauv kev; Dej-sodium metabolism thiab vascular tone tswj txoj hauv kev |
Cim npe nrov: CAS: 124584-08-3: Nesiritide, Tuam Tshoj CAS: 124584-08-3: Nesiritide manufacturers, lwm tus neeg, Hoobkas
